BUFFALO BILLS VS SAN FRANCISCO 49ERS | NFL FOOTBALL PICKS, PREDICTIONS AND ODDS | GUESS THE FINAL SCORE AND GET A PRICE $.

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Tommy D. our NFL expert takes a look at how both teams are playing and breaks down their numbers to support his prediction.

8:15 PM ET

OPEN:O/U: 48SF +2.5.     LIVE:O/U: 47SF -1

49ers are 13-3 ATS in their last 16 Monday games.

49ers are 7-3 ATS in their last 10 home games vs. a team with a winning road record.

49ers are 9-21-1 ATS in their last 31 games as a favorite.

49ers are 7-21-1 ATS in their last 29 games as a home favorite.

49ers are 1-4 ATS in their last 5 home games.

Bills are 5-0 ATS in their last 5 games after accumulating more than 150 yards rushing in their previous game.

Bills are 6-1-2 ATS in their last 9 games as a road underdog.

Bills are 5-2-1 ATS in their last 8 games on grass.

Bills are 9-4-2 ATS in their last 15 road games.