MLB Picks This Week: A Deep Dive Into the Action

By Tommy D,  Betting Analyst with Over 3 Decades in the Trenches

Let me tell you—if you’re ready to dive into MLB betting this week, you’ve come to the right place. With over a decade of experience, I can tell you there’s nothing quite like the thrill of picking the right games, watching the action unfold, and feeling that rush when your bet hits. This week’s MLB matchups are full of opportunities, so let’s break it down and get you prepped for the best picks.

We’ll go through five games this week that I’m particularly excited about. Whether you’re a seasoned bettor or someone just starting to dip their toes into the waters, I’ve got some solid insights to help guide your decisions. Let’s talk about some of the hottest teams, key player matchups, and betting strategies you won’t want to miss.

Blue Jays vs. Twins – June 6, 2025

Starting off with one of the biggest matchups this week, the Toronto Blue Jays are set to face off against the Minnesota Twins. If you’ve been following the Blue Jays, you know they’ve been looking sharp. Their young stars have been stepping up, especially with Vladimir Guerrero Jr. leading the charge. Their lineup is stacked, and they’ve got some serious power at the plate. But here’s the thing: Minnesota’s pitching has been one of the standout surprises this season. With Sonny Gray on the mound, the Twins have been a formidable force.

In terms of betting strategy, I see a lot of value in the Blue Jays moneyline. Toronto has been on a solid run lately, and with their high-powered offense, they should be able to put up enough runs to take this game. But don’t overlook the total runs bet—this could be one of those games where both teams trade punches, leading to a high-scoring affair.

Astros vs. Pirates – June 5, 2025

Next up, we’ve got the Houston Astros going head-to-head with the Pittsburgh Pirates. Now, this is an interesting one. Houston, as usual, is a team you can’t ignore. With Jose Altuve and Alex Bregman still doing their thing, they’ve been firing on all cylinders. But Pittsburgh? They’ve been scrappy, and sometimes those scrappy teams can sneak up on you. Pittsburgh has a knack for being under the radar, and their pitching has improved significantly over the last month.

When it comes to betting on this one, Astros -1.5 seems like a solid pick. Houston’s offense is just too much for the Pirates, and even though Pittsburgh has some solid arms, it’s hard to see them keeping up. If you’re looking to bet on the total, I’d lean toward the under, as Houston’s pitching staff is capable of shutting things down after a few early runs.

Cubs vs. Nationals – June 4, 2025

The Chicago Cubs have been a bit of a roller coaster this year, but they’ve had some excellent pitching performances and strong showings from Seiya Suzuki and Dansby Swanson. Meanwhile, the Washington Nationals have been, well, underwhelming. The Nats have had a tough time generating consistent offense and pitching, and that’s likely going to be their downfall in this series.

Chicago’s pitching has been relatively solid this year, especially with Marcus Stroman likely starting. His control and ability to limit hard contact could be the difference-maker here. If you’re looking for a straight-up pick, Cubs moneyline is probably your best bet. For a bit of extra action, I’d consider Cubs to cover -1.5 as well. Their bullpen has been solid, and they should be able to control this game throughout.

Rangers vs. Rays – June 3, 2025

Now, let’s talk about one of the most exciting teams this season—the Texas Rangers. They’ve been on fire, especially with the offense they’ve been putting up. Corey Seager, Marcus Semien, and the rest of the lineup have been hitting on all cylinders. The Tampa Bay Rays, however, are a completely different beast. Their pitching staff is one of the most underrated in the league, and their offense has been very consistent, especially when you’ve got guys like Wander Franco and Randy Arozarena stepping up.

This one is going to be tough to call, but I’m leaning toward Rays moneyline. Tampa Bay’s pitching staff is extremely capable of keeping Texas in check, and their offense can explode at any given moment. If you want to get a little more creative, consider betting on under 8 total runs. With Tampa’s solid pitching and the Rangers’ ability to strike out, this could be a relatively low-scoring game.

Mets vs. Dodgers – June 2, 2025

Finally, we wrap up with a real heavyweight matchup—the New York Mets vs. the Los Angeles Dodgers. This is always an exciting series, and with Max Scherzer potentially taking the mound for the Mets, this could be a game full of electric pitching. The Dodgers are tough as always, with Mookie Betts leading the charge, and their lineup depth makes them dangerous in any given matchup. However, the Mets’ pitching staff can go toe-to-toe with the best, and if Scherzer is on, they’ll be tough to beat.

For this game, I like Dodgers moneyline. Their offensive depth and experience in high-pressure situations often give them the edge. However, if you’re feeling bold, betting on Dodgers -1.5 could offer some decent value, especially if they explode offensively in the later innings.

Betting Strategy for This Week’s MLB Picks

Now, let’s talk strategy for a bit. The key to success with MLB betting isn’t just about picking the right teams—it’s about understanding the nuances of each game. You need to pay attention to pitching matchups, injuries, and momentum. It’s also vital to avoid going with your gut based solely on team name or record. Baseball is a game of streaks, and while some teams might seem like sure things, there are always surprises.

Make sure you’re doing your research, watching games, and staying updated on any injuries or line-up changes. Also, don’t get greedy. Betting smaller amounts on multiple games can often be more profitable than dumping everything on one or two high-risk bets. Keep your bets calculated, and you’ll see consistent returns.

Lastly, always remember to manage your bankroll wisely. MLB is a grind, and you need to make sure you’re pacing yourself over the course of a season, not just looking for a quick win.

Before I let you go and get in those bets, here’s a quick peek at some upcoming topics we’ll be diving into:

Stick around—more betting tips are on the way! For now, enjoy the MLB action and may your picks hit big this week.