07/05/25 Cardinals vs Cubs: MLB Expert betting analysis and predictions

Cardinals vs Cubs expert prediction, picks & odds   

The National League Central division race takes center stage at Wrigley Field this Saturday afternoon as the St. Louis Cardinals attempt to rebound from Friday’s crushing 11-3 defeat against the Chicago Cubs. With the Cubs firmly established as -148 favorites at home, this matchup presents intriguing betting opportunities for sharp bettors looking to capitalize on division rivalry dynamics.

The Cubs currently sit atop the NL Central with an impressive 53-35 record, while the Cardinals trail in third place at 47-42. This 6-game gap represents more than just standings – it reflects the divergent trajectories of these historic franchises entering the season’s crucial stretch.

Pitching Matchup: Veteran Savvy vs Rising Talent

Matthew Liberatore’s Redemption Quest

The Cardinals are entrusting their bounce-back hopes to 25-year-old southpaw Matthew Liberatore, who has transformed his command issues from last season into a strength. The young lefty enters Saturday’s contest with a solid 6-6 record, 3.70 ERA, and an impressive 1.16 WHIP across 92.1 innings in 16 starts.

Liberatore’s most encouraging development has been his enhanced strike zone control. After posting a concerning 28:76 walk-to-strikeout ratio in 2023, he’s dramatically improved to 17 walks against 76 strikeouts this season. This improvement suggests better pitch sequencing and confidence in his arsenal.

Against Chicago specifically, Liberatore has proven effective, delivering a seven-inning, two-run performance earlier this season that showcased his ability to navigate Cubs hitters. His previous success against this lineup provides the Cardinals with legitimate optimism for Saturday’s rematch.

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Drew Pomeranz’s Bullpen Brilliance

The Cubs counter with veteran left-hander Drew Pomeranz, whose 2024 campaign has been nothing short of spectacular. In 26 appearances (23.1 innings), Pomeranz has maintained a perfect 0.00 ERA while posting a microscopic 0.90 WHIP. His .177 batting average against demonstrates his ability to consistently retire opposing hitters.

Pomeranz’s track record against St. Louis this season includes two scoreless relief appearances, allowing just one hit across 2.0 innings. His familiarity with Cardinals hitters could prove decisive in high-leverage situations.

Recent Form Analysis: Momentum vs Motivation

The Cubs enter Saturday riding the wave of Friday’s offensive explosion, where they connected for six home runs in an 11-3 victory. The standout performers included Seiya Suzuki, Michael Busch (who launched three homers), Carson Kelly, Dansby Swanson, and Pete Crow-Armstrong. This power display showcased the depth of Chicago’s lineup and their ability to capitalize on mistake pitches.

St. Louis, meanwhile, managed just three hits for 31 at-bats in Friday’s loss, with their lone bright spot being Brendan Donovan‘s seventh home run of the season. The Cardinals’ 1-for-5 performance with runners in scoring position highlighted their offensive struggles when opportunities arose.

Division Dynamics and Betting Implications

The NL Central standings create an interesting betting narrative. Chicago is favored at -148 with the Cardinals as +126 underdogs, reflecting both the Cubs’ superior record and home-field advantage. However, division games often produce unexpected results, particularly when the underdog faces elimination-type pressure.

The Cubs’ first-place position means they’re playing with house money, while the Cardinals desperately need victories to remain relevant in the playoff conversation. This psychological dynamic often favors the team with more urgency, making the Cardinals’ underdog status potentially valuable.

Key Injury Considerations

St. Louis faces significant roster challenges with multiple key players listed on their injury report. First baseman Willson Contreras (hand) and third baseman Nolan Arenado (finger) are both questionable, while right fielder Jordan Walker remains out with appendicitis. These absences limit the Cardinals’ offensive flexibility and depth.

Chicago’s injury list is less concerning, with catcher Miguel Amaya (oblique) and several pitchers sidelined. However, none of these absences directly impact Saturday’s starting lineup or bullpen availability.

Advanced Metrics and Trends

The Cubs’ home performance has been particularly strong this season, contributing to their division-leading record. Wrigley Field’s unique characteristics, including wind patterns and day game conditions, often favor teams with superior plate discipline and power potential – areas where Chicago excels.

St. Louis has shown resilience in bounce-back scenarios throughout the season, particularly after lopsided losses. Their veteran leadership and championship experience provide intangible benefits that don’t always reflect in traditional statistics.

Betting Strategy and Value Assessment

The current line presents interesting value considerations. While the Cubs’ -148 moneyline reflects their superior position, the Cardinals’ +126 odds offer attractive potential returns for bettors believing in their bounce-back ability.

The run line becomes particularly interesting, with the Cardinals receiving +1.5 runs. Given the low-scoring nature of many division games and Liberatore’s recent success, this spread could provide value for those expecting a closer contest than Friday’s blowout.

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Insights

Will the Cubs’ offensive explosion continue into Saturday?

Friday’s six-home run performance represents an outlier, even for a talented Cubs lineup. Regression to the mean suggests Saturday’s game will likely feature more typical scoring patterns, especially with quality pitching on both sides.

How significant is Matthew Liberatore’s improved command?

Liberatore’s 28:76 to 17:76 walk-to-strikeout improvement represents genuine development rather than statistical noise. This enhanced control makes him a more reliable option in crucial division games.

Does home field advantage matter more in Cubs-Cardinals matchups?

Historical data suggests Wrigley Field provides the Cubs with measurable advantages against NL Central opponents, particularly in day games. The unique atmosphere and field dimensions favor Chicago’s approach.

What’s the betting significance of the Cardinals’ injury concerns?

The questionable status of Contreras and Arenado creates lineup uncertainty that could impact the Cardinals’ offensive capabilities. However, their veteran depth has proven capable of stepping up in crucial moments.

How should bettors approach the run total?

Friday’s high-scoring affair might inflate public perception of the run total. With quality starting pitching and typical regression patterns, Saturday’s game could feature more balanced scoring.

Are the Cardinals’ +126 underdog odds justified?

The odds reflect both the Cubs’ superior record and home-field advantage. However, division games often produce closer results than regular season records suggest, potentially making the Cardinals’ price attractive for contrarian bettors.

The Cardinals vs Cubs Saturday showdown presents a compelling betting opportunity for those willing to analyze beyond surface-level statistics. With quality pitching, division rivalry intensity, and meaningful implications for both teams’ playoff aspirations, this game deserves serious consideration from sharp bettors looking for value in the competitive NL Central race.